EXPERTISE
Preclinical Pharmacology
Oncology
Molecular Biology and Genetic Engineering
Stable and Transient Expression and Repression
Biomarkers
Imaging
Experimental Pharmacology
Proteolysis and Enzymology
Pharmaceutical Development: In Cellulo – In Vivo Transition
BIOGRAPHY
Frédéric holds a Ph.D. in biochemistry (Université de Sherbrooke, 2018) and specializes in preclinical pharmacology. He also specializes in molecular biology, which he has taught to undergraduate students in the University Certificate in Biotechnology at Laval University since 2019. He is a research member of INAF (U.Laval) and the CISSS-Chaudière-Appalaches research center. Frédéric also holds research funding from the FRQ for his work on non-invasive physiological sensors. He has been a researcher at TransBIOTech since 2017 and is currently the Head of the Pharmaceutical Sciences Department.
EDUCATION
Ph.D. – Biochemistry (University of Sherbrooke)
3rd -cycle Microprogram – Higher Education Pedagogy (University of Sherbrooke)
B.Sc. – Pharmacology (University of Sherbrooke)
RESEARCH THEMES
FUNDED PROJECTS
Publications
In Situ Non‐Invasive Imaging of Neutrophil Myeloperoxidase and Skin Reactive Oxygen Species in Experimental Murine Atopic Dermatitis; S Babity, S Pei, J Galimi, V Lapointe, D Brambilla, F Couture; Advanced Sensor Research 2 (9), 2300015
Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo. Katarina Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin, Stéphanie Hallée, Mario Harvey, Joannie Roberge, Frédéric Couture, Sajeev Kohli, Thomas J. Gross, David K. Meyerholz, Garrett R. Rettig, Bernice Thommandru, Gavin Kurgan, Christine Wohlford-Lenane, Dennis J.Hartigan-O'Connor, Gregory A. Newby, David R. Liu, Alice F. Tarantal, David Guay, Paul B. McCray, Jr.. Nature Communications 2023 Dec 5;14(1):8051.
Intralesional Treatment of Basal Cell Carcinoma in a Genetically Inducible Mouse Model; N Messier, F Couture, V Théberge, M Harvey, K Kobayashi; SKIN The Journal of Cutaneous Medicine 7 (2), s172-s172
Granulocyte pro-myeloperoxidase is redundantly processed by proprotein convertase furin and PC7 in HL-60 cells; V Lapointe, F Couture; Biochemistry and Cell Biology 102 (3), 275-284
Therapeutic Targeting of the Proteolytic Enzymes; F Couture; International Journal of Molecular Sciences 24 (1), 521
A Naked Eye‐Invisible Ratiometric Fluorescent Microneedle Tattoo for Real‐Time Monitoring of Inflammatory Skin Conditions; S Babity, F Couture, EVR Campos, S Hedtrich, R Hagen,D Fehr, M Bonmarin, D Brambilla; Advanced Healthcare Materials 11 (6), 2102070
Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function; S Babity, AK Polomska, F Couture, M Bonmarin, D Fehr, M Detmar, D Brambilla; Journal of Controlled Release 327, 350-359
