EXPERTISE
Preclinical Studies
Pneumology
Immunology
Microbiology
Imaging
Experimental Pharmacology
BIOGRAPHY
Carole-Ann Huppé holds a PhD in Clinical and Biomedical Sciences (Laval University), focused on understanding the role of pharmacological modulators in the management of pulmonary hypersensitivity diseases. Since then, she has gained extensive expertise across numerous scientific fields and further developed her knowledge, particularly in management, by completing an MBA in pharmaceutical management. Carole-Ann has been a researcher at TransBIOTech since 2020.
EDUCATION
Ph.D. – Clinical and Biomedical Sciences (Laval University)
M.B.A. – Pharmaceutical Management (Laval University)
B.Sc. – Microbiology (Laval University)
RESEARCH THEMES
FUNDED PROJECTS
Publications
Auger M., Sorroza-Martinez L. Brahiti N., Huppé CA., Faucher-Giguère L., Arbi I., Hervault M., Cheng X., Gaillet B.,Couture F., Guay D., Al-Halifa S. (2024). "Enhancing peptide and PMO delivery to mouse airway epithelia by chemical conjugation with the amphiphilic peptide S10." Mol Ther NucleicAcids 35(3): 102290.
Paris-Robidas S. Bolduc I. Lapointe V. Galimi J.Lemieux P. Huppé CA. Couture F. (2024). "Impact of time intervals on drug efficacy and phenotypic outcomes in acute respiratory distress syndrome. Sci Rep 14(1): 20768
Patoine D,Bouchard K, Blais-Lecours P, Courtemanche O, Huppé CA, Marsolais D,Bissonnette EY, Lauzon-Joset JF. (2023) CD200Fc limits dendritic cell and B cell activation during chronic allergen exposures. J Leukoc Biol. 114(1): 84-91.
Courtemanche O, Huppé CA, Blais Lecours P, Lerdu O, Roy J,Lauzon-Joset JF, Blanchet MR, Morissette MC, Marsolais D. (2022). "Co-modulation of T cells and B cells enhances the inhibition of inflammation in experimental hypersensitivity pneumonitis." Respir Res 23(1): 275.
Lechasseur A, Huppé CA, Talbot M, Routhier J,Aubin S, Beaulieu MJ, Duchaine C, Marsolais D, Morissette MC. (2020). Exposure to nicotine-free and flavor-free-cigarette vapors modifies the pulmonary response to tobacco cigarette smoke in female mice. Am J Physiol Lung Cell Mol Physiol., 319 (4):L717-L727.
Carole-Ann Huppé, Pascale Blais Lecours, Emilie Bernatchez, Jean-François Lauzon-Joset, Caroline Duchaine, Hugh Rosen, Geneviève Dion, Kelly M. McNagny, Marie-Renée Blanchet, Mathieu C. Morissette, David Marsolais. (2020). S1P1 contributes to endotoxin-enhanced B cell functions involved in hypersensitivity pneumonitis. American Journal of Respiratory Cell and Molecular Biology.
Huppé CA, Blais Lecours P, Lechasseur A, Gendron DR, Lemay A, Bissonnette E,Blanchet M, Duchaine C, Morissette MC, Rosen H and Marsolais D. (2018). S1P1 inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung. Mucosal immunology.
Gendron D, Blais Lecours P, Lemay A, Beaulieu M, Huppé CA, Lee-Gosselin A, Flamand N,Don A, Bissonnette E, Blanchet M, Laplante M, Bourgoin S, Bossé Y, Marsolais D.(2017) A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma.Frontiers in Phamacology.
Gendron D, Lemay A,Blais-Lecours P, Perreault-Vallières V, HuppéCA, Bossé Y, Blanchet M, Dion G, Marsolais D. (2016). FTY720 exerts paradoxical effects on fibrosis depending on its period of delivery after lung injury. Pulmonary Pharmacology and Therapeutics.
